Department of Biomedical Engineering
- B.Tech, ME, Indian Institute of Technology, Bombay, India
- Ph.D., BME, University of Texas at San Antonio / University of Texas Health Science Center at San Antonio
- Post-doc, Wake Forest Institute for Regenerative Medicine
Areas of Teaching Interest:
- Mechanics of Materials
- Micro Computed Tomography
- Tissue Engineering
- Fluid Mechanics
Areas of Research Interest:
- Bioreactors for musculoskeletal tissues
- Bone tissue engineering
- Interplay of biophysical and biochemical stimuli
- Cell and drug delivery for orthopedic regeneration
- Mechanical modeling of biological architectures
Description of Research:
My current interests are focused on developing regenerative strategies for bone and skeletal muscle tissue engineering. In specific, on-going projects focus on the employment of mechanical stimulation regimes in bioreactors to improve engraftment of bone and muscle substitutes. The compliance of substrates has a profound influence on the stem cell response and this effect is enhanced by applied mechanical loads. Studying the relative impact of these cues on directed cellular differentiation is important to develop appropriate materials for musculoskeletal interfaces, where there is a steep gradient in mechanical properties. This work is being carried out in close collaboration with Dr. Joseph Wenke’s group at the US Army Institute of Surgical Research.
In support of the tissue regeneration efforts, I work on the correlation of in vivo bone and vessel morphology using micro computed tomography or alternative image bases analyses to scaffold structure and bio-mechanical properties. The spatial architecture of tissue grafts and the resulting initial mechanical properties including strength and permeability directs the efficacy of these grafts to act as suitable substrates to direct tissue regeneration. The non-destructive evaluation of these properties along the translation of the scaffold from material synthesis, through in vitro testing and in vivo evaluation provides a powerful analysis tool with built in feedback for design improvements.
- T. Guda, S. Oh, M. Appleford, J.L. Ong, “Bilayer hydroxyapatite scaffolds for maxillofacial bone tissue engineering”, International Journal of Oral and Maxillofacial Implants, In Press.
- K.V. Brown, B. Li, T. Guda, D.S. Perrien, S.A. Guelcher, J.C. Wenke, “Improving bone formation in a rat femur segmental defect by controlling BMP-2 release”, Tissue Engineering A, 2011, Vol. 17, Iss. 13-14, pp:1735-1746.
- S.A. Guelcher, K.V. Brown, B. Li, T. Guda, B-H. Lee, J.C. Wenke “Dual-Purpose Bone Grafts Reduce Infection and Improve Healing”, Journal of Orthopedic Trauma, 2011, Vol. 25, Iss. 8, pp:477-82.
- T. Guda, J.A. Walker, B.E. Pollot, M.R. Appleford, S. Oh, J.L. Ong, J.C. Wenke, “ In vivo performance of bilayer hydroxyapatite scaffolds for bone tissue regeneration in the rabbit radius model”, Journal of Materials Science: Materials in Medicine, 2011, Vol. 22, Iss. 3, pp:647-56.
- J.S. Son, Guda Teja, M. Appleford, J.L. Ong, K. Park, D.K. Han, S. Oh, “Structure and characteristics of Novel Hydroxyapatite/Polylactide Bi-layered Porous Scaffold for Bone Regeneration”, Tissue Engineering and Regenerative Medicine, 2009, Vol. 6, Iss. 13, pp:1241-1251.
- B.M. Chesnutt, A.M. Viano, Y. Yuan, Y. Yang, J.L. Ong, T. Guda, W.O. Haggard, and J.D.Bumgardner, “Design and Characterization of a Novel Chitosan/ Nanocrystalline Calcium Phosphate Composite Scaffold for Bone Regeneration”, Journal of Biomedical Materials Research A, 2009, Vol. 88, Iss. 2, pp:491-502.
- X.N. Dong, T. Guda, H.R. Millwater, X. Wang, “Probabilistic failure analysis of bone using a finite element model of mineral-collagen composites”, Journal of Biomechanics, 2009, Vol. 42, Iss. 4, pp:202-209.
- T. Guda, M. Appleford, S. Oh, J.L. Ong, “A cellular perspective to bioceramic scaffolds for bone tissue engineering: the state of the art”, Current Topics in Medicinal Chemistry, 2008, Vol. 8, Iss.4, pp:290-299.
- T. Guda, T.A. Ross, L.A. Lang and H. Millwater, “Probabilistic analysis of preload developed in dental implant abutment screws”, Journal of Prosthetic Dentistry, 2008, Vol. 100, Iss.3, pp:183-193.