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Dr. Reilly Matthew, Ph.D.

Matthew A. Reilly, Ph.D.

Assistant Professor

Department of Biomedical Engineering

Educational Background:

  • B.Ch.E., University of Dayton
  • M.S., University of Dayton
  • Ph.D., Washington University in St. Louis

Areas of Teaching Interest:

  • Biomechanics
  • Instrumentation Development
  • Experimental Methods
  • Materials Characterization

Areas of Research Interest:

  • Fundamental:
    • Biomechanics
    • Instrumentation Development
    • Biomimetic Materials
    • Surface Modification
  • Application:
    • Biomimetic treatments for cataracts and presbyopia

 

Description of Research:

My primary research focuses on developing treatment for presbyopia and cataracts. Presbyopia is the gradual recession of the nearest point at which your eye can focus as you age. This condition affects all humans and primates and usually presents clinically around 40-45 years of age when the near focal point is no longer within arm's reach, making reading difficult. Presbyopia is most commonly treated with reading glasses or bifocals, though multifocal and progressive spectacle and intraocular lenses are also available. Cataract is the loss of transparency in the ocular lens and the leading cause of blindness worldwide. Cataract is treated by surgically replacing the opaque natural lens with a synthetic intraocular lens. This is the most commonly-performed surgical intervention in the United States, with over 2 million intraocular lens implantations performed each year, resulting in $6.8 billion in direct medical costs alone.

Current treatments for presbyopia and cataracts use optical techniques to give clear vision for reading and at long distances. Unfortunately, this leaves much of the world out of focus and usually still requires the patient to wear spectacles. My goal is to restore the body's natural ability to focus at all distances by mimicking the natural mechanism used by the young eye. This involves complex materials interactions and a detailed knowledge of the optical and mechanical properties of the natural lens, as well as materials which can reproduce these properties. My lab focuses on using novel instrumentation to measure the properties of the natural lens and candidate prosthetic materials. This experimental approach is coupled with bio-optomechanical modeling to understand the fundamental specifications which a prosthesis must achieve to be successful.

 

 

Selected Publications

  • MA Reilly, P Martius, HJ Burd, O Stachs, R Guthoff, An Automated Lens Spinning Rig With Environmental Control. Experimental Eye Research, submitted.
  • MA Reilly, KE Swindle-Reilly, N Ravi, In Situ-Forming Ophthalmic Prostheses, in: Novel biomedical hydrogels: biochemistry, manufacture, and medical applications. S. Rimmer, ed., Woodhead Publishing Ltd., Cambridge, UK, 118-148, 2011.
  • MA Reilly, UP Andley, Quantitative Biometric Phenotype Analysis in Mouse Lenses. Molecular Vision, 2010, 16:1041-1046.
  • UP Andley, MA Reilly, In Vivo Lens Deficiency of the R49C A-Crystallin Mutant. Experimental Eye Research, 2010, 90(6):699-702.
  • MA Reilly, N Ravi, A Geometric Model of Ocular Accommodation. Vision Research, 2010, 50:330-336.
  • H Du, PD Hamilton, MA Reilly, A d'Avignon, N Ravi, A facile synthesis of highly water-soluble, core-shell organo-silica nanoparticles with controllable size via sol-gel process. Journal of Colloid and Interface Science, 2009, 340:202-208.
  • MA Reilly, PD Hamilton, G Perry, N Ravi, Comparison of Natural and Refilled Porcine Lenses in a Robotic Lens Stretcher. Experimental Eye Research, 2009, 88(3):483-494.
  • MA Reilly, N Ravi, Microindentation of the Young Porcine Ocular Lens. Journal of Biomechanical Engineering, 2009, 131(4):044502.
  • MA Reilly, G Perry, N Ravi, An Inexpensive Microindentation Device with Electrical Contact Detection. Review of Scientific Instruments, 2009, 80(1):015105.
  • MA Reilly, B Rapp, PD Hamilton, AQ Shen, N Ravi, Material Characterization of Porcine Lenticular Soluble Proteins. Biomacromolecules, 2008, 9(6):1519-1526.
  • MA Reilly, PD Hamilton, N Ravi, Dynamic Multi-Arm Radial Lens Stretcher: A Machine Analog of the Ciliary Body. Experimental Eye Research, 2008, 86(1):157-164.

 

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