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 Jack L. Lancaster, Ph.D.Professor of Radiology Research Imaging Center
Educational Background: Areas of Research Interest: My research activities focus on theory, acquisition, and processing of 3-D images of humans and animals. The Research Imaging Center (RIC) houses several high-field MR imaging systems, two human PET imaging systems, and a dedicated small-animal PET imaging system. These tomographic imaging systems enable macroscopic measurements of numerous parameters of interest including blood flow, diffusion coefficients, T1, T2, proton density, electrical activity, just to mention a few. In vivo measurements associated with imaging research are approximately bounded by a spatial resolution of 1mm, temporal resolution ranging from milliseconds to minutes, and contrast resolutions above 5%. My research in modeling has lead to the development of new 3-D standardized models of the human brain, methods to assess myelin levels during early brain development, and a new theory of interactions of pulsed E-M fields in the brain. The roles of medical physicists and biomedical engineers are intertwined in the many research projects ongoing at the RIC, making it an excellent training ground for graduate and post graduate students interested in biomedical imaging research. I am a member of the Committees on Graduate Studies for the joint UTSA-UTHSCSA Biomedical Engineering Program and the UTHSCSA Radiological Sciences program, where I teach courses in advanced imaging concepts. I am also Co-Editor of the Human Brain Mapping journal and actively involved in groups developing standards for brain mapping. Selected Publications: Cykowski MD, Kochunov PV, Ingham RJ, Ingham JC, Mangin JF, Riviere D, Lancaster JL, Fox PT. Perisylvian Sulcal Morphology and Cerebral Asymmetry Patterns in Adults Who Stutter. Cereb Cortex. 2007 Jun 21. Kochunov P, Thompson PM, Coyle TR, Lancaster JL, Kochunov V, Royall D, Mangin JF, Riviere D, Fox PT. Relationship among neuroimaging indices of cerebral health during normal aging. Hum Brain Mapp. 2007 Feb 8. Lancaster JL, Tordesillas-Gutierrez D, Martinez M, Salinas F, Evans A, Zilles K, Mazziotta JC, Fox PT. Bias between MNI and Talairach coordinates analyzed using the ICBM-152 brain template. Hum Brain Mapp. 2007 Jan 31. Coyle TR, Kochunov P, Patel RD, Nery FG, Lancaster JL, Mangin JF, Riviere D, Pillow DR, Davis GJ, Nicoletti MA, Serap Monkul E, Fox PT, Soares JC. Cortical sulci and bipolar disorder. Neuroreport. 2006 Nov 6;17(16):1739-42. Kochunov P, Lancaster JL, Glahn DC, Purdy D, Laird AR, Gao F, Fox P. Retrospective motion correction protocol for high-resolution anatomical MRI. Hum Brain Mapp. 2006 Dec;27(12):957-62. Matsuo K, Glahn DC, Peluso MA, Hatch JP, Monkul ES, Nait P, Sanches M, Zamarripa F, LANCASTER JL, Fox PT, Gao JH, Soares JC. Prefrontal gyperactivation during working memory task in untreated individuals with major depressive disorder. Molecular Psychiatry, Epub May 19, 2006. Poline JB, Dtrother SC, Dehaene-Lambertz G, Egan GF, LANCASTER JL. Motivation and synthesis of the FIAC experiment: Reproducibility of fMRI results across expert analyses. Hum Brain Mapp, 27(5):351-359, 2006. Fox PT, Narayana S, Tandon N, Fox SPm Sandoval H, Kochunov P, Capaday C, LANCASTER JL. Intensity modulation of TMS-induced cortical excitaton: primary motor cortex. Hum Brain Mapp. 27(6):478-487, 2006. Kochunov P, Mangin JF, Lancaster J, Thompson P, Riviere D, Contepas Y, Regis J, Schlosser A, Royall RD, Zilles K, Mazziotta J, Fox P. Age-related morphology trends of cortical sulci. Human Brain Mapping, 26:210-220, 2005. Andrews TA, Lancaster JL. Dodd SJ, Contreras-Sesvold C, Fox PT. Testing the three-pool white matter model adapted for use with T2 relaxometry. Magnetic Resonance in Medicine 54:449-454, 2005. Lancaster JL, Laird AR, Fox PM, Glahn DE, Fox PT. Automated analysis of meta-analysis networks. Human Brain Mapping 25(1):174-184, 2005. Soares JC, Kochunov P, Monkul ES, Nicoletti MA, Bramballa P, Sassi RD, Mallinger AG, Frank E, Kupfer DJ, Lancaster J, Fox P. Structural brain changes in bipolar disorder using deformation field morphometry. Neuroreport 16(6):541-544, 2005. Lancaster JL, Cody JD, Andrews T, Hardies LJ, Hale DE, Fox PT. Myelination in children with partial deletions of chromosome 18q. American Journal of Neuroradiology 26:447-454, 2005 Feng C-M, Narayana S, Lancaster JL, Jerabek PA, Arnow TL, Zhu F, Tan LH, Fox PT, GaoJ-H. CBF changes during brain activation: fMRI vs. PET. NeuroImage 22:443-446, 2004. Lancaster JL, Narayana S, Wenzel D, Ludkemeyer J, Roby J, Fox P. Evaluation of an image-guided, robotically positioned transcranial magnetic stimulation system. Human Brain Mapping 22:329-340, 2004. Fox PT, Narayana S,Tandon N,Sandoval H, Fox SP,Kochunov P, Lancaster JL. Column-based model of electric field excitation of cerebral cortex. Human Brain Mapping 22(1):1-14, 2004. Lancaster JL, Kochunov PV, Thompson PM, Toga AW, Fox PT. Asymmetry of the brain surface from deformation field analysis. Human Brain Mapping 19:79-89, 2003. Szabo CA, Lancaster JL, Xiong J, Cook C, Fox P. MR Imaging Volumetry of Subcortical Structures and Cerebellar Hemispheres in Normal Persons. Am J Neuroradiol 24(4):644-7, 2003. Lancaster JL, Andrews T, Hardies LJ, Dodd S, Fox PT. A three-pool model of white matter. J Mag Res Img 17:1-10, 2003. Kochunov P, Lancaster J, Thompson P, Toga A, Brewer P, Hardies L, Fox P. An optimized individual target brain in the Talairach coordinate system. NeuroImage 17:922-927, 2003. Contact Information: University of Texas Health Science Center Phone: 210-567-8188 Fax: 210-567-8152 jlancaster@uthscsa.edu
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