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Biomedical Engineering Faculty


Stephen E. Harris, Ph.D.
Professor
Department of Periodontics & Cellular and Structural Biology

Educational Background:

  • Ph.D., U. of Texas at Austin in Biochemical Genetics, 1969.
  • NIH Postdoctoral Fellow at California Institute of Technology, Pasadena California 1970-1972

    Areas of Research Interest:
    Osteoblast Differentiation in Transgenic models and In Vitro; Gene Expression and Microarray analysis of mechanically responsive genes in osteocytes in both In Vitro models and In Vivo Models; Role of Bone Morphogenetic Proteins in osteoblast and osteocyte biology using transgenic models; Correlation of Mechanically Induced New Bone Formation with Strain Fields derived from Finite Element Analysis.

    Selected Publications:
    Zhao M, Qiao M, Harris SE, chen D, Oyajobi BO, Mundy GR. The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol Cell Biol. 2006 Aug; 26(16):6197-208.

    Gluhak-Heinrich J, Pavlin D, Harris SE, Gasparac Z, Macdougall M. Reciprical MEPE and DMP1 expresion in osteocytes during orthodontic treatment. J Dent Res; Vol. 85, no. A, Mar. P. 2084-2084, 2006.

    Harris SE, Guo D, Yang W, Harris MA, Gluhak-heinrich J, Edward J, Zhao M, Mundy GR, Anderson HC, Kream B, Lichtler A, Hogan B, Liu S, Quarles LD, Feng J, Mishina Y, Martin JF. BMP2 and BMP4 Action and Signaling in Bone: Conditional Deletion Studies in Mice. Conference on BMP‘s, p. 28-I16, 2006.

    Zhang J, Eick JD, Guo D, Dusevich V, Bonewald LF, Harris SE. BMP4 is essential for tooth terminal cytodifferentiation: Gain-loss function study. J Dent Res; vol. 84, no. A, Mar. p. 0030-0030, 2005.

    Zhang J, Harris SE, Eick JD, Vladimir D, Bonewald L, Macdougall MJ, Feng JQ. Transgenic targeting of BMP4 to ameloblast disrupts enamel maturation. J Dent Res; vol. 83, no. A, Mar. p. 2160-2160, 2004.

    Li X, Zhang Y, Kang H, Liu W, Liu P, Zhang J, Harris SE, Wu D. Sclerostin Binds to LRP5/6 and antagonizes canonical Wnt signaling. J Biol Chem. May 20;280(20):19883-7, 2005.

    Zhang Y, Want Y, LiX, Zhang J, Mao J, LiZ, Zheng J, Li L, Harris S, and Wu D. The LRP5 High-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. Mol and Cellular Biology 24(11): 4677-4684, 2004.

    Yang W, Lu Y, Kalajzic I, Guo D, Harris MA, Gluhak-Heinrich J, Kotha S, Bonewald LF, Feng JQ, Rowe DW, Turner CH, Robline AG, Harris SE. Dentin matrix protein 1 gene cis-regulation: Use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo. J. Biol. Chem. 280, May 27, 2005, 20680-20690.

    Xiaofeng Li, Peng Liu, Wenzhong Liu, Peter Maye, Jianghong Zhang, Yazhou Zhang, Marja Hurley, Caiying Guo, Adele Boskey, Le Sun, Stephen E Harris, David W Rowe, Hua Zhu Ke & Dianqing Wu. Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nature Genetics, September 2005, Vol 37, No. 9, pp945-952.

    Harris, Stephen E, Dayong Guo, Wuchen Yang, Yixia Xie, Jianghong Zhang, H. Clark Anderson, Marie A. Harris , Barbara Kream, Alex Lichtler, Brigid Hogan, Holger Kulessa , and Jian Q. Feng. BMP4 is Necessary for Bone and Dentin Formation Postnatally: Use of Bone and Tooth Selective Collagen Type I Cis-Regulatory Regions to Driving the Recombinase Cre in the Presence of Mouse Model In Which the BMP4 Gene Has Had LoxP sites Inserted Flanking Exon 3 and 4. Connective Tissue Research, In press. 2005.

    Kalajzic I, Braut A, Guo D, Jiang X, Kronenberg MS, Mina M, Harris MA, Harris SE, and Rowe DW. (2004). Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgenic. Bone 35:74-82,, 2004.

    Harris SE, Guo D, Harris MA, Krishnaswamy A, and Lichtler AC. Transcriptional regulation of BMP2 activated genes in osteoblasts using gene expression microarray analysis: Role of Dlx2 and Dlx5 Transcription Factors. Frontiers in BioScience 8: s1249-1265, September 1, 2003.

    Gluhak-Heinrich T, Bonewald LF, MacDougall M, Harris SE, Pavlin D. Mechanical Loading Stimulates Dentin Matrix Protein 1 (DMP1) in Osteocytes In Vivo. J Bone and Mineral Res. 18:807-817, 2003.

    Harris SE and Harris MA. Gene Expression profiling in Osteoblast Biology:Bioinformatic Tools. Molecular Biology Reports 28:139-156, 2002.

    Zhao M, Harris SE, Horn D, Geng Z, Nishimura R, Mundy GR, and Chen D. Type I BMP Receptor signaling is necessary for Normal murine postnatal bone formation. J. Cell Biol. 157(No.6) June 19:1049-1060, 2002.

    Contact Information:

    Department of Periodontics, Room 3.58U DTL
    University of Texas Health Science Center
    Phone: 210-567-3723
    Fax: 210-567-6858
    E-mail: harris@uthscsa.edu
    Harris Lab Website: http://periodontics.uthscsa.edu/HarrisLab/HarrisLab_home.htm

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