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Biomedical Engineering Faculty

Photo of Dr. FeldmanMarc D. Feldman, M.D.
Associate Professor of Medicine
Director, Interventional Research
Associate Director, Cardiac Catheterization Laboratories

Educational Background: M.D., University of Pennsylvania School of Medicine, 1981

Areas of Research Interest: Research interests include development of instrumentation to study cardiac mechanics in intact mouse hearts; nanotechnology stent to deliver drug and gene therapy through the barrier of atheroslerosis; and use of optical coherence tomography to predict subsequent rupture of atherosclerotic plaques and myocardial infarction.

Funding Sources:
Include the National Institutes of Health, American Heart Association, Veterans Administration, and Industry Sponsors.


Biotechnology for cardiovascular applications, including:
  1. Electrical engineering applications to manage patients with congestive heart failure. Admittance systems to determine right heart volume in patients with previous AICDs/bi-ventricular pacemakers/traditional pacemakers to warn patients of impending heart failure exacerbation. Admittance systems to determine ventricular function in transgenic mouse models of heart failure. Using the hearts motion to recharge implanted cardiac devices.
  2. Applications of optics to predict future heart attacks. Optical coherence tomography (OCT) uses near-infrared light refection from atherosclerotic plaque to provide structural resolution of fibrous cap thickness and lipid core size with a resolution of 10 microns, far superior to MRI, multi-slice CT, and ultrasound. Iron nanoparticles are being used in conjunction with OCT for the molecular identification of macrophages. OCT catheter systems are also being constructed for patient use.
  3. Application of nanotechnology to the development of the next generation of drug delivery stents. The current FDA drug delivery stents use polymer that can cause allergic reactions in patients. Techniques to attach and release drugs directly to metals without the use of polymers are being developed.

Selected Publications (selected from 148 peer reviewed publications):
Colston JT, Boylston WH, Feldman MD, Jenkinson CP, De La Rosa S, Barton A, Trevino RJ, Freeman GL, Chandrasekar B. Interleukin-18 knockout mice display maladaptive cardiac hypertrophy in response to pressure overload. Biochemical Biophysical Research Communications. In press 2007.

Oh J, Feldman MD, Kim J, Sanghi P, Kang, HW, Milner TE. Magneto-motive detection of tissue based macrophages by differential phase optical coherence tomography. Lasers in Medicine. In press, 2007.

Wei C-L, Valvano JW, Feldman MD, Nahrendorf M, Peshock R, Pearce JA. Volume catheter parallel conductance varies between end-systole and end-diastole. IEEE Transactions on Biomedical Engineering. In press 2007.

Ayon A, Cantu M, Chava, K, Agrawal, M, Feldman, MD, Johnson, D, Patel, Marton, D, Shi, Emily. Drug loading of nanoporous TiO2 Films. Journal of Biomedical Materials. 2006 Vol. 1, No. 4, L11-L15.

Johnson MD, Marton, D, Mahapatro A, Feldman MD, Devang, P, Ayon A. The use of alkanethiol self-assembled monolayers (SAMs) on 316L stainless steel for coronary artery stent nanomedicine applications: An Oxidative and in vitro stability study. Nanomedicine: Nanotechnology, Biology, and Medicine, 2006; Vol. 2; issue 2; 182-190.

Mani G, Feldman MD, Patel D, Agrawal CM. Coronary stents: A materials prospective. Journal of Biomaterials Research, 2007, Vol. 28 (9): 1689-1710.

Oh J, Feldman MD, Kim J, Condit C, Emelianov S, Milner TE. Detection of magnetic nanoparticles in tissue using magneto-motive ultrasound. Nanotechnology 17 (2006) 4183-4190.

Reyes M, Steinhelper ME, Alvarez JA, Escobedo D, Pearce J, Valvano JW, Pollock BH, Wei C-L, Kottam A, Altman, D, Bailey S, Thomsen S, Colston JT, Oh J-H, Freeman GL, Feldman MD. Impact of physiologic variables and genetic background on myocardial frequency-resistivity relations in the intact beating murine heart. AJP: Heart and
Circulatory Physiology. 2006 291:1659-1669.

Cilingiroglu M, Oh J-H, Sugunan B, Kemp NJ, Kim J, Lee S, Zaatari HN, Escobedo D, Thomsen S, Milner TE, Feldman MD. Detection of Vulnerable Plaque in a Murine Model of Atherosclerosis with Optical Coherence Tomography. Catheterization Cardiovascular Interventions. 2006; 67(6): 915-923.

Mahapatro DM, Johnson D, Patel DN, Feldman MD, Ayon AA, Agrawal CM: Surface Modification of Functional Self Assembled Monolayers (SAMs) on 316L stainless steel via lipase catalysis. Langmuir. 2006; 22(3): 901-905

Jonathan R. Nebeker MS MD, Renu Virmani MD, Charles L. Bennett MD PhD MPP, Jennifer M. Hoffman PhamD, Matthew H. Samore MD, Jorge Alvarez MD, Charles J. Davidson MD, June M. McKoy MD MPH JD, Denis W. Raisch PhD, Brian K Whisenant, Paul R. Yarnold PhD, Steven M. Belknap MD, Dennis P. West PhD, Jonathan E. Gage MD, Richard E. Morse MA, Gordana Gligoric MD PhD, Laura Davidson, Marc D. Feldman MD. Hypersensitivity cases associated with drug-eluting coronary stents. JACC 2006; 47(1): 175-181.

Charles L Bennett MD PhD MPP, Jonathan R. Nebeker MS MD, E. Allison Lyons BA, Matthew H. Samore MD, Marc D. Feldman MD, June M. McKoy MD JD MPH, Kenneth R Carson MD, Steven M. Belknap MD, Steven M.Trifilio RPH, Glen T. Schumock PharmD MBA, Paul R. Yarnold PhD, Charles J. Davidson MD, Andrew M. Evens DO, Richard E. Morse MA, Timothy M. Kuzel MD, Jorge P. Parada MD MPH, Denis Cournoyer MD, Dennis P. West PhD, Oliver Sartor MD, Martin S. Tallman MD, Dennis W Raisch PhD. Introducing RADAR: The Research on Adverse Drug events And Reports (RADAR) project. JAMA. 2005; 293: 2131-2140.

Wei CL, Valvano JW, Feldman MD, Pearce JA. Nonlinear conductance-volume relationship for murine conductance catheter measurement system. IEEE Transactions on Biomedical Engineering 2005; 52(10): 1654-1661.

Raghavan K, Wei CL, Kottman A, Altman DG, Fernandez DJ, Reyes M, Valvano JW, Feldman MD, Pearce JL. Design and instrumentation and data acquisition system for complex admittance measurement. Biomedical Sciences Instrumentation, 2004; 40: 453-457.

Alvarez JA, Reyes M, Escobedo D, Freeman GL, Steinhelper ME, Feldman MD. Enhanced left ventricular systolic function early in type 2 diabetic mice: clinical implications. Diabetes and Vascular Research, 2004; 1: 89-94.

Reyes M, Escobedo D, Lee S, Steinhelper M, Freeman GL, Feldman MD. Enhancement of contractility with sustained afterload: blunting of length dependent activation. Circulation, 2003; 107: 2962-2968.

Villard JW, Feldman MD, Kim J, Milner TE, Freeman GL. Use of a blood substitute to determine instantaneous murine RV thickening with optical coherence tomography. Circulation, 2002; 105: 1843 - 1849.

Zile MR, Gaasch WH, Carroll JD, Feldman MD, Aurigemma GP, Schaer GL, Ghali JK, Liebson PR. Diastolic heart failure: is measurement of left ventricular diastolic function necessary to make a diagnosis? Circulation, 2001; 104: 779-782.

Bailey S, Feldman MD, Polin J, Agawal M. Endothelial seeding of gas-plasma treated polymer. Cardiac Vascular Regeneration 2000;1, 178-188.

Bennett CL, Connors JM, Bell WR, McCarthy LJ, Sarode R, Tarantolo S, Hatfield AJ, Michalets EL, Feldman MD, Davidson CL,Tsai HM. Thrombotic thrombocytopenic purpura associated with clopidogrel. NEJM, 2000; 342: 1773-1777

Contact Information:

Department of Medicine, Room 5.642U DTL
Division of Cardiology
University of Texas Health Science Center
Phone: 210-567-2106
Fax: 210-567-6960
E-mail: Feldmanm@uthscsa.edu

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