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Biomedical Engineering Faculty

Yusheng Feng, Ph.D.
Associate Professor
Department of Mechanical Engineering

Educational Background:
B.S. Tsinghua University (China)
M.S. University of Oklahoma
Ph.D. University of Texas at Austin

Areas of Research Interest:

  • Computational Oncology, Treatment Planning, and Prognosis Simulation
  • Image-Guided Surgical Control and Optimization
  • Bioheat Transfer in Heterogeneous Media (Vascular Tumors)
  • Nanoparticle-Mediated Thermal Therapeutic Simulation
  • Cellular Mechanics (Cell Adhesion and Cancer Cell Metathesis Modeling)
  • Characterization of Heat Shock Proteins (HSP27, HSP60, HSP70)
  • Parallel Computing for Large Biological Systems

    • Dr. Feng is an engineer and applied mathematician by training. He has been working in mathematical modeling and computer simulation for last fifteen years with applications ranging from aerospace, semiconductor, nanoscience and technology, to biomedical engineering. He has been focusing in the area of cancer treatment simulation and outcome optimization and image-guided control for last three years and has developed broad collaboration with medical community at M.D. Anderson Cancer Center in Houston and UT Health Science Center at San Antonio (UTHSCSA). He was on of the major team member in a NSF/DDDAS project "Collaborative Research on a Dynamic Data-Driven System for Laser Treatment of Cancer" (http://dddas.ices.utexas.edu). Last year, he received a five-year career award from NIH/NCI and is working on "MRTI Guided Integrative Model for Cancer Treatment." This is a coveted and distinguished award that is highly competitive and given to individuals who wish to use their quantitative and analytical skills and redirect their focus on applications to biomedical problems. Dr. Feng is currently an associate professor in the departments of mechanical engineering at UT San Antonio (UTSA) and serves as the director of Computational Bioengineering and Nanotechnology Lab
    (http://engineering.utsa.edu/~mechanical/faculty_staff/Feng.html). Lately, He became a core faculty member lately for the UTSA/UTHSCSA Joint Graduate Program in Biomedical Engineering. He plans to offer a new course on Computational Oncology and Cancer Treatment Simulations in Fall 2008. Dr. Feng has three ongoing projects: (1) Treatment planning, optimization, and real-time surgical control for laser treatment of prostate cancer in collaboration with UT Austin and M.D. Anderson Cancer Center, (2) Nanotube-mediated thermal therapy simulation in collaboration with Virginia Tech, and (3) Mechanistic study of cell adhesion and its effect on cancer metathesis induced by protein-protein interaction.

    Selected Publications (selected from over 31 peer reviewed manuscripts, book chapters and proceedings):

    Oden JT, Patra A, Feng Y. Parallel Adaptive hp Finite Element Methods for Fluid and Solid mechanics. Recent Developments in Finite Element Analysis, Edited by Hughes,TJR, Onate, E, Zienkiewicz, OC. 1994;29-36, 1994.

    Oden, JT, Feng, Y. Local and Pollution Error Estimation for Finite Element Approximations of Elliptic Boundary Value Problems. J. Computational and Applied Mathematics 74:245-293, 1996.

    Oden, JT, Feng, Y, Prudhomme, S. Local and Pollution Error Estimation for Stokesian Flows. In'l J. for Numerical Methods in Fluids 27:33-39, 1998

    Oden JT, Babuska I, Nobile F, Feng Y, Tempone R. Theory and Methodology for Estimation and Control of Errors due to Modeling, Approximation, and Uncertainty. Comput. Methods Appl. Mech Eng 194:193-204, 2005

    Feng, Y, Rylander, MN, Bass, J, Diller, KR. Optimal Design of Laser Surgery for Cancer Treatment Through Nanoparticle-Mediated Hyperthermia Therapy. NSTI-Nanotech 1:39-42, 2005.

    Rylander MN, Feng Y, Stafford RJ, Bass J, Hazle J, Diller, KR. Design of Optimal Hyperthermia Protocols for Prostate Cancer by Controlling HSP Expression Through Computer Modeling. SPIE Symposium on Biomedical Optics, 5698-24, 2005.

    Rylander MN, Feng Y, Bass J, Diller KR. Thermally-Induced Injury and Heat Shock Protein Response in Cells and Tissues. Ann. N.Y. Acad. Sci.1066:222-242, 2005.

    Oden JT, Diller KR, Bajaj C, Browne JC, Hazle J, Babuska I, Bass J, Demkowicz L, Feng Y, Fuentes D, Prudhomme S, Rylander MN, Stafford RJ, Zhang Y. Development of a computational paradigm for laser treatment of cancer. ICCS Part III, Lecture Notes Comp. Sci. 3993, Alexandrov VN et al. (eds.), Springer-Verlag, 530-537, 2006.

    Rylander MN, Feng Y, Zhang J, Bass J, Stafford, RJ, Hazle, JD, Diller, KR. Optimizing HSP Expression Induced by Prostate Cancer Laser Therapy through Predictive Computational Models. J. Biol. Optics 11(4), 041113:1-16, 2006.

    Oden JT, Diller KR, Bajaj C, Browne JC, Hazle J, Babuska I, Bass J, Demkowicz L, Elliott A, Feng Y, Fuentes D, Prudhomme S, Rylander MN, Stafford RJ, and Zhang Y. Dynamic Data-Driven Finite Element Models for Laser Treatment of Cancer. Num Meth PDE, 23(4), 904-922, 2007.

    Bajaj C, Oden JT, Diller KR, Browne JC, Hazle, J, Babuška I, Bass J, Bidaut L, Demkowicz L, Elliott A, Feng Y, Fuentes D, Kwon B, Prudhomme S, Stafford RJ, and Zhang Y, Using Cyber-Infrastructure for Dynamic Data Driven Laser Treatment of Cancer, Lecture Notes in Computer Science Shi Y, et al (eds), 4487:972-979, 2007.

    Rylander MN, Feng Y, Bass J, and Diller KR. Heat Shock Protein Expression and Damage Optimization for Laser Therapy Design. Lasers in Surgery and Medicine, 39:731-746, 2007.

    Feng Y, Fuentes D, Hawkins A, Rylander MN, Elliott A, Stafford J, Oden JT, Nanoshell-Mediated Laser Surgery Simulation for Prostate Cancer Treatment. Special Issue of Computational Bioengineering, Engineering with Computers (Accepted for publication), 2007.

    Feng Y, Fuentes D, Hawkins A, Oden JT. MRTI-Based Optimization and Real-Time Laser Surgical Control for Cancer Treatment Using Fast Inverse Analysis Techniques. IEEE Proceedings of Int Conf Biomed Eng Informatics. (Accepted for publication), 2008.

    Feng Y, Oden JT, Rylander MN. A Two State Cell Damage Model: Theory and in vitro Experiments, J. Biomech Eng. (In review), 2008.

    Contact Information:

    Department of Mechanical Engineering, EB 3.04.14
    University of Texas at San Antonio
    Phone: 210-458-6479
    Fax: 210-458-6504
    yusheng.feng@utsa.edu

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