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Educational Background:
Areas of Research Interest: My research activities focus on three main areas. The first area of interest is the application of fluorescence and Raman spectroscopy/microscopy for tissue or cell molecular identification and characterization in real time using live cell imaging and nanoparticles optics. This is a joint effort with colleagues in the UT Health Science Center at San Antonio, UTSA, and Purdue University to develop applications for clinical diagnosis, tissue engineering, and drug development. The second area focuses on the application of advanced signal processing, image processing, and statistical pattern recognition techniques to biomedical signal analysis and modeling. Examples are 1) feature extraction and classification of ECG and blood pressure waveform for the diagnosis of cardiovascular diseases; 2) development of non-invasive estimation of cardiac output for real-time monitoring of trauma patients; and 3) three-dimensional CT image analysis of bone structure for stress estimation. The third area of focus is the development of medical devices by a multidisciplinary team including physicians, researchers, and engineers (electrical, mechanical, optical, and software), according to ISO quality procedures. Selected Publications: Ling J, Takatani S, Noon GP, Nose Y. "In vivo studies of reflectance pulse oximeter sensor," Proceedings of the SPIE, 1887: 256-262, 1993. Takatani S, Orime Y, Tasai K, Ohara Y, Naito K, Mizuguchi K, Makinouchi K, Ling J, Noon GP, Nose Y. "Totally implantable TAH and VAD with multipurpose miniature electromechanical energy system," Artificial Organ, 18(1): 80-92, 1994. Takatani S, Ling J. "Optical oximetry sensors for whole blood and tissue," IEEE Engineering in Medicine and Biology Magazine, 13(3): 247-357, 1994. Ling J, Ohara Y, Orime Y, Noon GP, Takatani S. "Clinical evaluation of a new oscillometric blood pressure monitoring system in adults and children based on the 1992 AAMI SP-10 Standards," Journal of Clinical Monitoring, 11(2): 123-130, 1995. Ling J, Bovik AC. "Smoothing low SNR molecular images via anisotropic median-diffusion," IEEE Transaction on Medical Imaging, 21(4): 377-384, 2002. Ling J, Weitman SD, Miller MA, Moore RV, Bovik AC. "Direct Raman imaging techniques for studying the subcellular distribution of a drug," Applied Optics, 41(28): 6006-6017, 2002. Ling J. "Raman Micro-spectroscopy and Imaging of Active Pharmaceutical Ingredients in Cells," in Pharmaceutical Applications of Raman Spectroscopy, Slobodan Sasic (ed.), John Wiley & Sons, 221-255, 2007. Contact Information: 6220 Culebra Road San Antonio, TX 78238 Phone:210-522-3953 Fax: 210-684-6147 jling@swri.org |
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