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Educational Background:
Areas of Research Interest: The research in Dr. Shepherd's laboratory has the goal of developing new analytical instruments for clinical use. The first phase of this work consists of fundamental biophysical studies to delineate the optical properties of tissues such as blood because new insights into the roles of light scattering and absorbance can provide a rational basis for the design of oximeters, co-oximeters, laser-Doppler blood flowmeters, and other instruments that depend on the optical properties of biological tissues. The second phase of this work consists of designing, building, and testing the new optical instruments, while a third phase examines the efficacy of the new instruments in clinical applications. At this time, instruments designed and developed in Dr. Shepherd's laboratory are used in hundreds of hospitals throughout the US and 18 other countries. Selected Publications: Shepherd AP, Terpolilli BM, Steinke JM. A hand-held device to measure oxygen uptake: performance characteristics, patient selection and the propagation of its measurement error into fick cardiac output determinations. J Invasive Cardiol. 2007 Mar;19(3):113-22. Steinke, J. M., Gong, A.K., and Shepherd, A.P. Rapid spectrophotometric measurements of total bilirubin in intact and hemolyzed blood: a feasibility study. J. Perinatology 21(6): 382-387, 2001. Ali, G.S., Ali, A.A., Steinke,J.M. and Shepherd, A.P. A simple method for measuring fetal hemoglobin by CO-Oximetry. Clinica Chimica Acta 307(1-2): 249-52, 2001. Ali, A. A., Ali, G.S., Steinke, and Shepherd, A.P. Co-oximetry interference by hemoglobin-based blood substitutes. Anesthesia & Analgesia 92: 863-869, 2001. Shepherd, A.P., Steinke, J.M. C-oximetry interference by perflubron emulsion: comparison of hemolyzing and nonhemolyzing instruments. Clin Chem 44(10):2183-90, 1998. Shepherd, A.P., Steinke, J.M. and McMahan, C.A. Effect of oximetry error on the diagnostic value of the Qp/Qs ratio. International Journal of Cardiology 61 (3): 247-259, 1997. Shepherd, A.P. and McMahan, C.A. Role of oximeter error in the diagnosis of shunts. Cath. & Cardiovas. Diagnosis 37: 435-446, 1996. Shepherd, A.P., Randal,V.T., Steinke, J.M. and Schmalzel, J.L. An oximeter for measuring hemoglobin concentration and oxygen content. Amer. J. Physiol. 257: H1705-1711, 1989. Contact Information: University of Texas Health Science Center Phone: 210-567-4356 Fax: 210-567-4410 shepherd@uthscsa.edu |
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