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Biomedical Engineering Faculty

Merry L. Lindsey, Ph.D.
Assistant Professor
Department of Medicine, Division of Cardiology

Educational Background:
B.A., Boston University
Ph.D., Baylor College of Medicine
Postdoctoral, Brigham and Women's Hospital and Harvard Medical School

Areas of Research Interest:
My laboratory is focused on studies relating to cardiac extracellular matrix biology, specializing in changes to the matrix that are the cause or effect of pathophysiological processes. These changes include cell-matrix interactions, which both affect and react to processes involved in tissue repair. My laboratory primarily uses the murine model of myocardial infarction (MI). In addition to physiological parameters, we also measure biochemical, cell biological, and proteomic outputs. The main foci of my laboratory are: 1) the role of macrophage-derived matrix metalloproteinases (MMPs) in left ventricular (LV) remodeling post-MI; 2) the role of the cardiac fibroblast in the remodeling process; and 3) the influence of aging on LV remodeling.

Research Techniques:
Matrix metalloproteinase assays, in vivo myocardial injury models (myocardial infarction and transverse aortic constriction models), murine cardiovascular function analyses, two-dimensional gel electrophoresis, fibroblast tissue culture, macrophage functional assays.

Selected Publications:
Lindsey, ML, Goshorn, D.K., Comte-Walters, S., Hendrick, J.W., Hapke, E., Zile, M.R., and Schey, K. A Multidimensional Approach to Identify Hypertrophy-Associated Proteins. Proteomics, 2006, 6:2225-2235.

Lindsey, ML, Escobar, GP, Dobrucki, LW, Goshorn, DK, Bouges, S., Mingoia, JT, McClister Jr., DM, Su, H, Gannon, J, MacGillivray, C, Lee, RT, Sinusas, AJ, and Spinale, FG. Matrix Metalloproteinase-9 Gene Deletion Facilitates Angiogenesis Following Myocardial Infarction. American Journal of Physiology (Heart and Circulation Physiology) 2006, 290(1): H232-239.

Squires, CE, Escobar, GP, Payne, JF, Leonardi, RA, Goshorn, DK, Sheats, N.J., Mains, I.M., Mingoia, JT, Flack, EC, and Lindsey, ML. Altered Fibroblast Function Following Myocardial Infarction. Journal of Molecular and Cellular Cardiology, 2005, 39(4): 699-707.

Lindsey, ML, Goshorn, DK, Squires, CE, Escobar, GP, Hendrick, JW, Mingoia, JT, Sweterlitsch, SE, and Spinale, FG. Age-Dependent Changes in Myocardial Matrix Metalloproteinase / Tissue Inhibitor of Metalloproteinase (MMP/TIMP) Profiles and Fibroblast Function. Cardiovascular Research, 2005, 66: 410-419.

Lindsey, ML. MMP Induction and Inhibition in Myocardial Infarction. Heart Failure Reviews, 2004. 9(1): 1-17.

Lindsey, ML, Mann, DL, Entman, ML, and Spinale, FG. Extracellular matrix remodeling following myocardial injury. Annals of Medicine, 2003. 35(5): p. 316 - 326.

Contact Information:

Department of Medicine, Room 5.630U DTL
Division of Cardiology
University of Texas Health Science Center
Phone: 210-567-4673
Fax: 210-567-6960
lindseym@uthscsa.edu

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