Description of Research:
Dr. Agrawal specializes in the area of orthopedic and cardiovascular biomaterials. His primary interests lie in the areas of tissue engineering and drug delivery. Currently his lab is investigating the effects of the architecture of tissue engineering scaffolds on nutrient supply and cell behavior. It is also using tissue engineering approaches to establish in vivo models for coronary artery disease. In the area of drug delivery his group is developing new techniques to tether drug molecules to metal surfaces using self assembled monolayers (SAMs). His work in these fields has resulted in several patents, many of which have been licensed to commercial entities.
Honors & Awards:
During his professional career, Dr. Agrawal has been the recipient of several honors and awards, and has authored more than 270 scientific publications and 18 patents. He is a Fellow of the American Institute for Medical and Biological Engineering-an honor reserved for those deemed to represent the top 2 percent of this profession. He has been elected the 2006 President of the Society for Biomaterials (membership comprising 25 countries), and was the Program Chair of the Annual Scientific Meeting of this society for 2001. Additionally, he is a member of the following professional groups: American Academy of Orthopaedic Surgeons, Tissue Engineering Society, Sigma XI Society, Orthopaedic Research Society, American Society for Testing and Materials, and Biomedical Engineering Society. Dr. Agrawal also serves on the editorial boards of the Journal of Biomedical Materials Research, Journal of Biomedical Materials Research (Applied Biomaterials), Tissue Engineering, Nanomedicine and the Journal of ASTM International.
Books
- "Engineering Biomaterials for Medical Applications" Vol 1. Eds. T.S. Hin, c.M. Agrawal, 2004
- "Synthetic Bone Graft Substitutes" Ed. Cato Laurencin; section editor: C.M.Agrawal, ASTM STP ISBN 0-8031-3356-1, 2003.
- Synthetic Bioabsorbable Polymers for Implants" Eds. C.M. Agrawal, J. Parr, S. Lin, ASTM STP 1396. ISBN 0-8031-2870-3, 2000.
- Proceedings, 17th Southern Biomedical Engineering Conference", Eds. C.M. Agrawal, K.A. Athanasiou, pub. Southern Biomedical Engineering Conf., Minneapolis, 1998, ISBN 0-7803-4512-6
Book Chapters
- X. Wang, K.A. Athanasiou and C.M. Agrawal: 'Fracture Toughness Tests of Bone-Implant Interfaces', Mechanical Testing of Bone and the Bone-Implant Interface, eds. Y. A. An and R. A. Draughn, CRC Press, Boca Raton, 1999.
- C.M. Agrawal, J. Mabrey, and D.M. Micallef: 'The Wear of Ultrahigh Molecular Weight Polyethylene', in the Encyclopedic Handbook of Biomaterials and Bioengineering, ed. D.Wise et al., Marcel Dekker, New York, 1995.
- K.A. Athanasiou, G. Niederauer, and C.M. Agrawal: 'Applications of Biodegradable Lactides and Glycolides in Podiatry', Clinics in Podiatric Medicine and Surgery, ed. A.S. Landsman, W.B. Saunders Co., Philadelphia, p 475-496, 1995.
- C.M. Agrawal, K.A. Athanasiou, G. Niederauer, and D.M. Micallef: 'The Use of PLA/PGA in Orthopaedic Implants', in the Encyclopedic Handbook of Biomaterials and Bioengineering, ed. D. Wise et al., Marcel Dekker, New York, 1995.
Selected Publications
- Mani G, Feldman MD, Patel D, Agrawal CM. Coronary stents: a materials perspective. Biomaterials. 2007 Mar;28(9):1689-710.
- Lavery LA, Higgins KR, Lanctot DR, Constantinides GP, Zamorano RG, Athanasiou KA, Armstrong DG, Agrawal CM. Preventing diabetic foot ulcer recurrence in high-risk patients: use of temperature monitoring as a self-assessment tool. Diabetes Care. 2007 Jan;30(1):14-20.
- Mahapatro A, Johnson DM, Patel DN, Feldman MD, Ayon AA, Agrawal CM. The use of alkanethiol self-assembled monolayers on 316L stainless steel for coronary artery stent nanomedicine applications: an oxidative and in vitro stability study. Nanomedicine. 2006 Sep;2(3):182-90.
- John G. Fleischli, Terese J. Laughlin, Kyriacos Athanasiou, Dan R. Lanctot, Lawrence Lavery, Xiaodu Wang, C. Mauli Agrawal, "The Effect Of Diabetes Mellitus On The Material Properties Of The Distal Tibia", J. Am. Podiatric Medical Association 96(2), 2006.
- Anil Mahapatro, David M. Johnson, Devang N. Patel, Marc D. Feldman, Arturo A. Ayon, and C. Mauli Agrawal; "Surface Modification of Functional Self Assembled Monolayers (SAMs) on 316L Stainless Steel via Lipase Catalysis", Langmuir, accepted 2006.
- McMullin, B; Agrawal, C.M. et al., Correlating Subjective and Objective Descriptors of Ultra High Molecular Weight Wear Particles From Total Joint Prostheses, Biomaterials, 27(5), 752-757, 2005.
- Lavery, L.A.; Lanctot, D.R.; Constantinides, G.; Zamorano, R.G.; Athanasiou, K.A.; Agrawal, C.M.: Wear and biomechanical characteristics of a novel shear reducing insole with implications for high-risk persons with diabetes. Diabetes Technology and Therapeutics, 7(4), 638-646, 2005.
- Chance, J.R.; Kragh, J.F., Jr.; Agrawal, C.M., Basamania, C.J.: Pullout Forces of Sutures in Muscle Lacerations. Orthopaedics, 28(10): 1187-90, 2005.
- Karande, T.S., Ong, J.L., Agrawal, C.M.: Diffusion in musculoskeletal tissue engineering scaffolds: design issues related to porosity, permeability, architecture, and nutrient mixing. Ann Biomed Eng, 32(12): 1728-43, 2004.
- Sweigart, M.A.; Zhu, C.F.; Burt, D.M.; DeHoll, P.D.; Agrawal, C.M.; Clanton, T.O.; Athanasiou, K.A.: Intraspecies and interspecies comparison of the compressive properties of the medial meniscus. Ann Biomed Eng, 32(11): 1569-79, 2004.
- Lavery, L.A.; Higgins, K.R.; Lanctot, D.R.; Constantinides, G.P.; Zamorano, R.G.; Armstrong, D.G.; Athanasiou, K.A.; Agrawal, C.M.: Home monitoring of foot skin temperatures to prevent ulceration. Diabetes Care, 27(11): 2642-47, 2004.
- Paruchuru, S.P.; Wang, X.; Agrawal, C.M.: Use of compact sandwich specimen to determine the critical strain energy release rate of bone. Journal of Biomedical Materials and Engineering. Accepted.
- Kim, K-H.; Agrawal, C.M.; Ong, J.L: Interaction of hydroxyapatite- titanium at elevated temperature in vacuum environment. Biomaterials. 25(15): 2927-32, 2004.
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